Nasal potential difference to detect Na+channel dysfunction in acute lung injury

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Nasal potential difference to detect Na+ channel dysfunction in acute lung injury.

Pulmonary fluid clearance is regulated by the active transport of Na(+) and Cl(-) through respiratory epithelial ion channels. Ion channel dysfunction contributes to the pathogenesis of various pulmonary fluid disorders including high-altitude pulmonary edema (HAPE) and neonatal respiratory distress syndrome (RDS). Nasal potential difference (NPD) measurement allows an in vivo investigation of ...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology

سال: 2011

ISSN: 1040-0605,1522-1504

DOI: 10.1152/ajplung.00223.2010